The Qian lab is interested in plant genome editing and engineering for sustainable and precision agriculture. We are seeking development of tools for the advancement of plant functional genomics, epigenome research and genomics-based crop improvements.
Selected Publications:
Chen J, Liu J, Jiang J, Qian S, Song J, Kabara R, Delo I, Serino G, Liu F, Hua Z, Zhong X. F-box protein CFK1 interacts with and degrades de novo DNA methyltransferase in Arabidopsis. New Phytol. 2020 Nov 20; PubMed PMID: 33216996.
Yang Z, Qian S, Scheid RN, Lu L, Chen X, Liu R, Du X, Lv X, Boersma MD, Scalf M, Smith LM, Denu JM, Du J, Zhong X. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat Genet. 2018 Sep;50(9):1247-1253. PubMed PMID: 30082787; PubMed Central PMCID: PMC6556434.
Qian S, Lv X, Scheid RN, Lu L, Yang Z, Chen W, Liu R, Boersma MD, Denu JM, Zhong X, Du J. Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun. 2018 Jun 21; 9(1):2425. PubMed PMID: 29930355; PubMed Central PMCID: PMC6013494.
Lu L, Chen X, Qian S, Zhong X. The plant-specific histone residue Phe41 is important for genomewide H3.1 distribution. Nat Commun. 2018 Feb 12;9(1):630. PubMed PMID: 29434220; PubMed Central PMCID: PMC5809374.
Chen X, Lu L, Qian S, Scalf M, Smith LM, Zhong X. Canonical and Noncanonical Actions of Arabidopsis Histone Deacetylases in Ribosomal RNA Processing. Plant Cell. 2018 Jan;30(1):134-152. PubMed PMID: 29343504; PubMed Central PMCID: PMC5810568.
Chen X, Lu L, Mayer KS, Scalf M, Qian S, Lomax A, Smith LM, Zhong X. POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. Elife. 2016 Nov 22;5PubMed PMID: 27873573; PubMed Central PMCID: PMC5119886.
Shi L, Li S, Shen F, Li H, Qian S, Lee DH, Wu JZ, Yang W. Characterization of nucleosome positioning in hepadnaviral covalently closed circular DNA minichromosomes. J Virol. 2012 Sep; 86(18):10059-69. PubMed PMID: 22787202; PubMed Central PMCID: PMC3446612.
Qian S, Zhong X, Yu L, Ding B, de Haan P, Boris-Lawrie K. HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):605-10. PubMed PMID: 19122141; PubMed Central PMCID: PMC2626750.
Hartman TR, Qian S, Bolinger C, Fernandez S, Schoenberg DR, Boris-Lawrie K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat Struct Mol Biol. 2006 Jun;13(6):509-16. PubMed PMID: 16680162.